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Publications

Selected Publications

Peri-Operative Neurocognitive Research Team Laboratory
Left: Alzheimer's Disease Related Processes that have also been shown to be modulated by Anesthetic Drugs and Surgical Stress. -from Berger M et al, JCTVA, 2014.
Right: Processes that have been implicated in the Pathophysiology of Perioperative Neurocognitive Disorders. -from Berger M et al, Anesthesiology, 2018

2025

  • Thornton MA, Marten EL, Lunardi N, Mai D, Macdonald C, Baker JG, Hitzeman A, Skinner CS, Brown CJ, Berger M, Lee SC, Cullum CM, Makris KI, Pham TH, Naik A, Tang V, Balentine CJ. Learning How Preoperative Communication Relates to Postoperative Experiences for Older Veterans Having Inguinal Hernia Surgery. J Am Geriatr Soc. 2026 Jan;74(1):177-185. doi: 10.1111/jgs.70216. Epub 2025 Nov 26. PubMed PMID: 41294300
  • Cher BAY, Lunardi N, Thornton M, Hitzeman A, Baker J, Macdonald C, Skinner CS, Brown CJ, Mai D, Marten EL, Makris K, Heredia MLM, Berger M, Cullum CM, Lee SC, Pham TH, Balentine CJ. Identifying Barriers and Motivators to Increase Surgical Clinical Trial Participation for Older Veterans. J Am Geriatr Soc. 2026 Jan;74(1):161-168. doi: 10.1111/jgs.70218. Epub 2025 Nov 26. PubMed PMID: 41294297.
  • Ning MH, Rodionov A, Ross JM, Ozdemir RA, Burch M, Lian SJ, Alsop D, Cavallari M, Dickerson B, Fong T, Jones RN, Libermann T, Marcantonio E, Santarnecchi E, Schmitt EM, Touroutoglou A, Travison T, Acker L, Smith MR, Sun H, Westover MB, Pascual-Leone Á, Berger M, Inouye SK, Shafi M. Prediction of postoperative delirium in older adults from preoperative cognition and occipital alpha power from resting-state electroencephalogram. Age Ageing. 2025 Oct 30;54(11). doi: 10.1093/ageing/afaf330. PubMed PMID: 41222553.
  • Zou H, Lutz MW, Foster MW, Wright MC, Violette MJ, Luo S, Laskowitz D, Devinney MJ, Berger M. Effects of Non-Cardiac/Non-neurologic Surgery and Anaesthesia on the CSF Proteome, and Modulation by the APOE Mimetic Peptide CN-105. medRxiv. 2025 Oct 7;. doi: 10.1101/2025.10.06.25337433. PubMed PMID: 41282803; PubMed Central PMCID: PMC12632645.
  • Yurashevich M, Habib AS, Berger M. Cerebrospinal fluid proteome of patients with persistent pain and/or postpartum depression after elective cesarean delivery: An exploratory prospective cohort study: Reply. J Clin Anesth. 2025 Sep;106:111943. doi: 10.1016/j.jclinane.2025.111943. Epub 2025 Jul 24. PubMed PMID: 40712327.
  • Das S, Devinney MJ, Berger M, Brown CH 4th. Mind the messenger: role of extracellular vesicle signalling in postoperative neurocognitive dysfunction. Br J Anaesth. 2025 Apr 17:S0007-0912(25)00155-2.
  • Reese M, Wright MC, Roberts KC, Browndyke JN, Bennett M, Acker L, Devinney MJ, Reekes TH, Waligorska T, Shaw LM, Blennow K, Zetterberg H, Cohen HJ, Mathew JP, Whitson HE, Westover MB, Woldorff MG, Berger M; MADCO-PC, INTUIT, PRIME, and MARBLE study groups. Associations between anaesthetic dose-adjusted intraoperative EEG alpha power, processing speed, and postoperative delirium: analysis of data from three prospective studies. Br J Anaesth. 2025 Apr 10:S0007-0912(25)00090-X.
  • Reekes TH, Upadhya VR, Merenstein JL, Cooter-Wright M, Madden DJ, Reese MA, Boykin PC, Timko NJ, Moul JW, Garrigues GE, Martucci KT, Cohen HJ, Whitson HE, Mathew JP, Devinney MJ, Zetterberg H, Blennow K, Shaw LM, Waligorska T, Browndyke JN, Berger M; MADCO-PC and INTUIT Investigators. Predilection for Perplexion: Preoperative microstructural damage is linked to postoperative delirium. medRxiv [Preprint]. 2025 Jan 9:2025.01.08.24319243.
  • Sieber F, McIsaac DI, Deiner S, Azefor T, Berger M, Hughes C, Leung JM, Maldon J, McSwain JR, Neuman MD, Russell MM, Tang V, Whitlock E, Whittington R, Marbella AM, Agarkar M, Ramirez S, Dyer A, Friel Blanck J, Uhl S, Grant MD, Domino KB. 2025 American Society of Anesthesiologists Practice Advisory for Perioperative Care of Older Adults Scheduled for Inpatient Surgery. Anesthesiology. 2025 Jan 1;142(1):22-51. doi: 10.1097/ALN.0000000000005172. PubMed PMID: 39655991.
  • Devinney MJ, Spector AR, Wright MC, Thomas J, Avasarala P, Moretti E, Dominguez JE, Smith PJ, Whitson HE, Veasey SC, Mathew JP, Berger M; and the INTUIT Study Investigators. The Role of Sleep Apnea in Postoperative Neurocognitive Disorders Among Older Noncardiac Surgery Patients: A Prospective Cohort Study. Anesth Analg. 2025 Jan 1;140(1):99-109.
  • Devlin JW, Sieber F, Akeju O, Khan BA, MacLullich AMJ, Marcantonio ER, Oh ES, Agar MR, Avelino-Silva TJ, Berger M, Burry L, Colantuoni EA, Evered LA, Girard TD, Han JH, Hosie A, Hughes C, Jones RN, Pandharipande PP, Subramanian B, Travison TG, van den Boogaard M, Inouye SK; Network for Investigation of Delirium: Unifying Scientists (NIDUS) Writing Group. Advancing Delirium Treatment Trials in Older Adults: Recommendations for Future Trials From the Network for Investigation of Delirium: Unifying Scientists (NIDUS). Crit Care Med. 2025 Jan 1;53(1):e15-e28.

2024

  • Reese M, Wong MK, Cheong V, Ha CI, Cooter Wright M, Browndyke J, Moretti E, Devinney MJ, Habib AS, Moul JW, Shaw LM, Waligorska T, Whitson HE, Cohen HJ, Welsh-Bohmer KA, Plassman BL, Mathew JP, Berger M; Markers of Alzheimer’s Disease and neuroCognitive Outcomes after Perioperative Care (MADCO-PC) Investigators. Cognitive and Cerebrospinal Fluid Alzheimer’s Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls. Anesthesiology. 2024 May 1;140(5):963-978.
  • Vasunilashorn SM, Wolfson E, Berger M, Leung J, Ware EB, Baccarelli A, Jones RN, Ngo LH, Marcantonio ER, Inouye SK, Kind AJH. Multi-level social determinants of health, inflammation, and postoperative delirium in older adults. J Am Geriatr Soc. 2025 Jan;73(1):279-282. doi: 10.1111/jgs.19159. Epub 2024 Aug 29.
  • Reese M, Wong MK, Cheong V, Ha CI, Cooter Wright M, Browndyke J, Moretti E, Devinney MJ, Habib AS, Moul JW, Shaw LM, Waligorska T, Whitson HE, Cohen HJ, Welsh-Bohmer KA, Plassman BL, Mathew JP, Berger M; Markers of Alzheimer’s Disease and neuroCognitive Outcomes after Perioperative Care (MADCO-PC) Investigators. Cognitive and Cerebrospinal Fluid Alzheimer’s Disease-related Biomarker Trajectories in Older Surgical Patients and Matched Nonsurgical Controls. Anesthesiology. 2024 May 1;140(5):963-978.
  • Reich KM, Gill SS, Eckenhoff R, Berger M, Austin PC, Rochon PA, Nguyen P, Goodarzi Z, Seitz DP. Association between surgery and rate of incident dementia in older adults: A population-based retrospective cohort study. J Am Geriatr Soc. 2024 May;72(5):1348-1359.
  • Acker L, Wong MK, Wright MC, Reese M, Giattino CM, Roberts KC, Au S, Colon-Emeric C, Lipsitz LA, Devinney MJ, Browndyke J, Eleswarpu S, Moretti E, Whitson HE, Berger M, Woldorff MG; INTUIT and PRIME study groups. Preoperative electroencephalographic alpha-power changes with eyes opening are associated with postoperative attention impairment and inattention-related delirium severity. Br J Anaesth. 2024 Jan;132(1):154-163.

2023

  • Devinney MJ, Wong MK, Wright MC, Marcantonio ER, Terrando N, Browndyke JN, Whitson HE, Cohen HJ, Nackley AG, Klein ME, Ely EW, Mathew JP, Berger M; MADCO-PC and INTUIT Study Teams. Role of Blood-Brain Barrier Dysfunction in Delirium following Non-cardiac Surgery in Older Adults. Ann Neurol. 2023 Dec;94(6):1024-1035.
  • Reese M, Christensen S, Anolick H, Roberts KC, Wong MK, Wright MC, Acker L, Browndyke JN, Woldorff MG, Berger M; MADCO-PC and INTUIT Investigators. EEG pre-burst suppression: characterization and inverse association with preoperative cognitive function in older adults. Front Aging Neurosci. 2023 Aug 30;15:1229081.
  • Villalobos D, Reese M, Wright MC, Wong M, Syed A, Park J, Hall A, Browndyke JN, Martucci KT, Devinney MJ, Acker L, Moretti EW, Talbot L, Colin B, Ohlendorf B, Waligorska T, Shaw LM, Whitson HE, Cohen HJ, Mathew JP, Berger M. Perioperative changes in neurocognitive and Alzheimer’s disease-related cerebrospinal fluid biomarkers in older patients randomised to isoflurane or propofol for anaesthetic maintenance. Br J Anaesth. 2023 Aug;131(2):328-337.
  • Berger M, Ryu D, Reese M, McGuigan S, Evered LA, Price CC, Scott DA, Westover MB, Eckenhoff R, Bonanni L, Sweeney A, Babiloni C. A Real-Time Neurophysiologic Stress Test for the Aging Brain: Novel Perioperative and ICU Applications of EEG in Older Surgical Patients. Neurotherapeutics. 2023 Jul;20(4):975-1000.

2022

  • Berger M, Browndyke JN, Cooter Wright M, Nobuhara C, Reese M, Acker L, Bullock WM, Colin BJ, Devinney MJ, Moretti EW, Moul JW, Ohlendorf B, Laskowitz DT, Waligorska T, Shaw LM, Whitson HE, Cohen HJ, Mathew JP; MADCO-PC Investigators. Postoperative changes in cognition and cerebrospinal fluid neurodegenerative disease biomarkers. Ann Clin Transl Neurol. 2022 Feb;9(2):155-170.
  • Cooter Wright M, Bunning T, Eleswarpu SS, Heflin MT, McDonald SR, Lagoo-Deenadalayan S, Whitson HE, Martinez-Camblor P, Deiner SG, Berger M. A Processed Electroencephalogram-Based Brain Anesthetic Resistance Index Is Associated With Postoperative Delirium in Older Adults: A Dual Center Study. Anesth Analg. 2022 Jan 1;134(1):149-158.
  • Oyeyemi DM, Cooter M, Chung S, Whitson HE, Browndyke JN, Devinney MJ, Smith PJ, Garrigues GE, Moretti E, Moul JW, Cohen HJ, Mathew JP, Berger M; MADCO-PC Study Team Investigators. Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults. J Geriatr Psychiatry Neurol. 2022 Jan;35(1):145-154.
  • Berger M, Cooter M, Roesler AS, Chung S, Park J, Modliszewski JL, VanDusen KW, Thompson JW, Moseley A, Devinney MJ, Smani S, Hall A, Cai V, Browndyke JN, Lutz MW, Corcoran DL; and Alzheimer’s Disease Neuroimaging Initiative. APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid. J Alzheimers Dis. 2021;79(2):511-530. doi: 10.3233/JAD-200747. Erratum in: J Alzheimers Dis. 2022;90(3):1339-1340.

2021

  • VanDusen KW, Li YJ, Cai V, Hall A, Hiles S, Will Thompson J, Arthur Moseley M, Cooter M, Acker L, Levy JH, Ghadimi K, Quiñones QJ, Devinney MJ, Chung S, Terrando N, Moretti EW, Browndyke JN, Mathew JP, Berger M; MADCO-PC Investigators. Cerebrospinal Fluid Proteome Changes in Older Non-Cardiac Surgical Patients with Postoperative Cognitive Dysfunction. J Alzheimers Dis. 2021 Feb 26.
  • Nobuhara CK, Berger M. Risk of Spinal Hematoma After Lumbar Puncture. JAMA. 2021 Feb 23;325(8):787-788.
  • Terrando N, Park JJ, Devinney M, Chan C, Cooter M, Avasarala P, Mathew JP, Quinones QJ, Maddipati KR, Berger M. Immunomodulatory lipid mediator profiling of cerebrospinal fluid following surgery in older adults. Sci Rep. 2021 Feb 4;11(1):3047.
  • Balentine CJ, Meier J, Berger M, Reisch J, Cullum M, Lee SC, Skinner CS, Brown CJ. Using Local Anesthesia for Inguinal Hernia Repair Reduces Complications in Older Patients. J Surg Res. 2021 Feb;258:64-72.
  • Meier J, Berger M, Hogan T, Reisch J, Zeh H, Cullum CM, Lee SC, Skinner CS, Brown CJ, Balentine CJ. Using local rather than general anesthesia for inguinal hernia repair may significantly reduce complications for frail Veterans. Am J Surg. 2021 Jan 22.
  • Velkers C, Berger M, Gill SS, Eckenhoff R, Stuart H, Whitehead M, Austin PC, Rochon PA, Seitz D. Association Between Exposure to General Versus Regional Anesthesia and Risk of Dementia in Older Adults. J Am Geriatr Soc. 2021 Jan;69(1):58-67.
  • Berger M, Cooter M, Roesler AS, Chung S, Park J, Modliszewski JL, VanDusen KW, Thompson JW, Moseley A, Devinney MJ, Smani S, Hall A, Cai V, Browndyke JN, Lutz MW, Corcoran DL. APOE4 Copy Number-Dependent Proteomic Changes in the Cerebrospinal Fluid. J Alzheimers Dis. 2021;79(2):511-530.

2020

  • Oyeyemi DM, Cooter M, Chung S, Whitson HE, Browndyke JN, Devinney MJ, Smith PJ, Garrigues GE, Moretti E, Moul JW, Cohen HJ, Mathew JP, Berger M. Relationship Between Depression/Anxiety and Cognitive Function Before and 6 Weeks After Major Non-Cardiac Surgery in Older Adults. J Geriatr Psychiatry Neurol. 2020 Dec 30;:891988720978791.
  • Berger M, Ghadimi K. Necessary Heroes and Ethos, from Fighting Nazis to COVID-19. Anesthesiology. 2020 Dec 1;133(6):1307-1310.
  • Balentine CJ, Meier J, Berger M, Hogan TP, Reisch J, Cullum M, Zeh H, Lee SC, Skinner CS, Brown CJ. Using local rather than general anesthesia for inguinal hernia repair is associated with shorter operative time and enhanced postoperative recovery. Am J Surg. 2020 Aug 25.
  • Vasunilashorn SM, Devinney MJ, Acker L, Jung Y, Ngo L, Cooter M, Huang R, Marcantonio ER, Berger M. A New Severity Scoring Scale for the 3-Minute Confusion Assessment Method (3D-CAM). J Am Geriatr Soc. 2020 Aug;68(8):1874-1876.
  • Nobuhara CK, Bullock WM, Bunning T, Colin B, Cooter M, Devinney MJ, Ferrandino MN, Gadsden J, Garrigues G, Habib AS, Moretti E, Moul J, Ohlendorf B, Sandler A, Scheri R, Sharma B, Thomas JP, Young C, Mathew JP, Berger M. A protocol to reduce self-reported pain scores and adverse events following lumbar punctures in older adults. J Neurol. 2020 Jul;267(7):2002-2006.
  • Klinger RY, Bottiger B, Berger M. A Plague on Both Your Monitors! Are Bispectral Index and Cerebral Oximetry Useful for Reducing Postoperative Cognitive Impairment?. J Cardiothorac Vasc Anesth. 2020 May;34(5):1182-1183.
  • Wang P, Velagapudi R, Kong C, Rodriguiz RM, Wetsel WC, Yang T, Berger M, Gelbard HA, Colton CA, Terrando N. Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia. Alzheimers Dement. 2020 May;16(5):734-749.
  • Berger M, Mark JB, Kreuzer M. Of Parachutes, Speedometers, and EEG: What Evidence Do We Need to Use Devices and Monitors?. Anesth Analg. 2020 May;130(5):1274-1277.
  • Berger M, Cooter M, Ni K, Thomas J, Gupta DK, Kertai MD. Response to ‘Correlation between bispectral index and age-adjusted minimal alveolar concentration’ (Br J Anaesth 2020; 124:e8). Br J Anaesth. 2020 Mar;124(3):e38-e39.
  • Cooter M, Ni K, Thomas J, Gupta DK, Hopkins TJ, Miller TE, James ML, Kertai MD, Berger M. Age-dependent decrease in minimum alveolar concentration of inhaled anaesthetics: a systematic search of published studies and meta-regression analysis. Br J Anaesth. 2020 Jan;124(1):e4-e7.
  • VanDusen KW, Eleswarpu S, Moretti EW, Devinney MJ, Crabtree DM, Laskowitz DT, Woldorff MG, Roberts KC, Whittle J, Browndyke JN, Cooter M, Rockhold FW, Anakwenze O, Bolognesi MP, Easley ME, Ferrandino MN, Jiranek WA, Berger M. The MARBLE Study Protocol: Modulating ApoE Signaling to Reduce Brain Inflammation, DeLirium, and PostopErative Cognitive Dysfunction. J Alzheimers Dis. 2020;75(4):1319-1328.
Complete Pubmed Publications